Galphai generates multiple Pins activation states to link cortical polarity and spindle orientation in Drosophila neuroblasts.

@article{Nipper2007GalphaiGM,
  title={Galphai generates multiple Pins activation states to link cortical polarity and spindle orientation in Drosophila neuroblasts.},
  author={Rick W Nipper and Karsten H. Siller and Nicholas Robert Smith and Chris Q Doe and Kenneth E Prehoda},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 36},
  pages={14306-11}
}
Drosophila neuroblasts divide asymmetrically by aligning their mitotic spindle with cortical cell polarity to generate distinct sibling cell types. Neuroblasts asymmetrically localize Galphai, Pins, and Mud proteins; Pins/Galphai direct cortical polarity, whereas Mud is required for spindle orientation. It is currently unknown how Galphai-Pins-Mud binding is regulated to link cortical polarity with spindle orientation. Here, we show that Pins forms a "closed" state via intramolecular GoLoco… CONTINUE READING

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