Galpha-mediated inhibition of developmental signal response.

@article{Brzostowski2002GalphamediatedIO,
  title={Galpha-mediated inhibition of developmental signal response.},
  author={Joseph A Brzostowski and Cynthia T. Johnson and Alan R. Kimmel},
  journal={Current biology : CB},
  year={2002},
  volume={12 14},
  pages={
          1199-208
        }
}
BACKGROUND Seven-transmembrane receptor (7-TMR)-G protein networks are molecular sensors of extracellular signals in all eukarya. These pathways cycle through activated (sensitized) and inhibited (desensitized) states, and, while many of the molecular components for signal activation have been described, inhibitory mechanisms are not well characterized. In Dictyostelium, 7-TM cAMP receptors direct chemotaxis and development but also regulate the periodic synthesis of their own ligand, the… CONTINUE READING

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