• Medicine
  • Published in Circulation research 2000

Galpha(i2) but not Galpha(i3) is required for muscarinic inhibition of contractility and calcium currents in adult cardiomyocytes.

@article{Nagata2000Galphai2BN,
  title={Galpha(i2) but not Galpha(i3) is required for muscarinic inhibition of contractility and calcium currents in adult cardiomyocytes.},
  author={Koichi Nagata and Cheng Ye and Monica Jain and David S. Milstone and Ronglih Liao and Richard M. Mortensen},
  journal={Circulation research},
  year={2000},
  volume={87 10},
  pages={
          903-9
        }
}
Parasympathetic stimulation of the heart acts through M(2)-muscarinic acetylcholine receptors to regulate ion channel activity and subsequent inotropic status. Although muscarinic signal transduction is mediated via pertussis toxin-sensitive G proteins Galpha(i/o), the specific signal transduction requirements of Galpha(i2) and Galpha(i3) in mediating muscarinic regulated L-type calcium currents (I(Ca, L)), intracellular calcium, and cell contractility remain to be determined. Adult ventricular… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 29 CITATIONS

Hypotensive property of Chenopodium ambrosioides in anesthetized normotensive rats.

  • Journal of complementary & integrative medicine
  • 2014
VIEW 1 EXCERPT
CITES BACKGROUND