Gallstone disease

  title={Gallstone disease},
  author={Hanns-Ulrich Marschall and Curt Einarsson},
  journal={Journal of Internal Medicine},
Gallstone disease is one of the most prevalent gastrointestinal diseases with a substantial burden to health care systems that is supposed to increase in ageing populations at risk. Aetiology and pathogenesis of cholesterol gallstones still are not well defined, and strategies for prevention and efficient nonsurgical therapies are missing. This review summarizes current concepts on the pathogenesis of cholesterol gallstones with focus on the uptake and secretion of biliary lipids and special… 

The prevalence and risk factors for gallstone disease

The prevalence and risk factors associated with gallstone disease are reviewed to lead to the development of better therapeutic and preventive strategies for dealing with this disease.

Gallstone disease: from genes to evidence-based therapy.

EASL Clinical Practice Guidelines on the prevention, diagnosis and treatment of gallstones.

Clinical Practice Guidelines on the prevention , diagnosis and treatment of gallstones q European Association for the Study of the Liver ( EASL ) ⇑

The EASL Clinical Practice Guidelines (CPG) on the prevention, diagnosis and therapy of gallstones aim to provide current recommendations on the following issues.

Acute gallbladder disease

The incidence, aetiology, presentation and management of gallbladder disease is outlined and Adjustments to lifestyle may help prevent the development of gall Bladder disease.

Ursodeoxycholic acid therapy in gallbladder disease, a story not yet completed.

A brief review of recent developments in UDCA use, current indications for its use and, the more recent advances in understanding its effects in terms of an anti-inflammatory drug are provided.

Uncommon complications of biliary stones

This article presents 5 patients with an atypical presentation of gallstone disease, and discusses the importance of knowing how to identify and treat these patients.

Dissecting the genetic heterogeneity of gallbladder stone formation.

The recent findings related to the genetics of cholelithiasis are summarized, the "inventory" of human lithogenic genes is updated, and the genetic studies to the pathobiologic background of the disease are related.

Concept of the pathogenesis and treatment of cholelithiasis.

Gallstone disease is one of the most prevalent gastrointestinal diseases with a substantial burden to health care systems and corticosteroids and oral contraceptives, which contain hormones related to steroid hormones, may be regarded as a model system of cholelithiasis development in man.

The characteristics of small intestinal bacterial overgrowth in patients with gallstone diseases

Small intestinal bacterial overgrowth might be prevalent in gallstone disease, including cases involving cholecystectomy and gallstones, and the prevalence and characteristics of SIBO in patients with gallstones are investigated.



Mechanisms of Disease: the genetic epidemiology of gallbladder stones

Data from recent identical twin, family and linkage studies provide conclusive evidence for a strong genetic component to gallstone disease and epidemiologic studies in at-risk populations indicate that gallstone formation is caused by multiple environmental influences and common genetic factors and their interactions.

Contribution of silent gallstones in gallbladder cancer

  • M. Tewari
  • Medicine
    Journal of surgical oncology
  • 2006
The author has reviewed the current understanding on silent gallstones and gallbladder carcinoma and raised the important question of the implications of leaving asymptomatic gallstones untouched.

The genetic background of cholesterol gallstone formation: an inventory of human lithogenic genes.

  • F. LammertS. Matern
  • Biology
    Current drug targets. Immune, endocrine and metabolic disorders
  • 2005
The evidence for common genetic determinants of human gallstone disease in general is summarized and an inventory of human lithogenic genes is provided to establish new targets for rational drugdesign for this exceptionally prevalent and economically significant digestive disease.

Role of diet in cholesterol gallstone formation.

Prevalence of gallbladder disease in hyperlipoproteinemia

It is suggested that certain forms of disturbances of lipoprotein metabolism are associated with an increased risk for development of gallbladder disease.

Prevention of cholesterol gallstone disease by FXR agonists in a mouse model

Cholesterol gallstone disease is characterized by several events, including cholesterol precipitation in bile, increased bile salt hydrophobicity and gallbladder inflammation. Here, we describe the

The Relation of Physical Activity to Risk for Symptomatic Gallstone Disease in Men

This longitudinal study studied whether regular leisure-time physical activity would decrease the incidence of newly symptomatic gallstone disease in a large cohort of U.S. male health professionals and examined the association of vigorous physical activity, nonvigorous physicalactivity, and sedentary behavior in relation to risk for symptomaticgallstone disease.

Review article: agents affecting gall‐bladder motility – role in treatment and prevention of gallstones

Patients at high risk of gallstone disease, and patients who are treated chronically with gall‐bladder motility inhibiting drugs, may benefit from improved gall‐blast motility using a prokinetic agent, but there are no long‐term studies to prove that such a strategy prevents gallstone formation.

Gallstones in cystic fibrosis: A critical reappraisal

It is concluded that radiolucent gallstones of cystic fibrosis are not of the conventional cholesterol type.