Gallstone disease

@article{Marschall2007GallstoneD,
  title={Gallstone disease},
  author={Hanns-Ulrich Marschall and Curt Einarsson},
  journal={Journal of Internal Medicine},
  year={2007},
  volume={261}
}
Gallstone disease is one of the most prevalent gastrointestinal diseases with a substantial burden to health care systems that is supposed to increase in ageing populations at risk. Aetiology and pathogenesis of cholesterol gallstones still are not well defined, and strategies for prevention and efficient nonsurgical therapies are missing. This review summarizes current concepts on the pathogenesis of cholesterol gallstones with focus on the uptake and secretion of biliary lipids and special… Expand
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Dissecting the genetic heterogeneity of gallbladder stone formation.
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The characteristics of small intestinal bacterial overgrowth in patients with gallstone diseases
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References

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TLDR
The physical-chemical mechanisms of gallstone formation in bile and the active role of the gallbladder and the intestine are discussed, and gaps in knowledge of the pathogenesis of gallstones formation and the potential for gene targeting in therapy are discussed. Expand
Mechanisms of Disease: the genetic epidemiology of gallbladder stones
TLDR
Data from recent identical twin, family and linkage studies provide conclusive evidence for a strong genetic component to gallstone disease and epidemiologic studies in at-risk populations indicate that gallstone formation is caused by multiple environmental influences and common genetic factors and their interactions. Expand
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TLDR
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TLDR
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TLDR
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Cholesterol gallstone disease is characterized by several events, including cholesterol precipitation in bile, increased bile salt hydrophobicity and gallbladder inflammation. Here, we describe theExpand
The Relation of Physical Activity to Risk for Symptomatic Gallstone Disease in Men
TLDR
This longitudinal study studied whether regular leisure-time physical activity would decrease the incidence of newly symptomatic gallstone disease in a large cohort of U.S. male health professionals and examined the association of vigorous physical activity, nonvigorous physicalactivity, and sedentary behavior in relation to risk for symptomaticgallstone disease. Expand
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TLDR
Patients at high risk of gallstone disease, and patients who are treated chronically with gall‐bladder motility inhibiting drugs, may benefit from improved gall‐blast motility using a prokinetic agent, but there are no long‐term studies to prove that such a strategy prevents gallstone formation. Expand
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