Gallium nitrate (NSC‐15200) induced toxicity in the rat. A pharmacologic, histopathologic and microanalytical investigation

  title={Gallium nitrate (NSC‐15200) induced toxicity in the rat. A pharmacologic, histopathologic and microanalytical investigation},
  author={R. Newman and A. Brody and I. Krakoff},
  • R. Newman, A. Brody, I. Krakoff
  • Published 1979
  • Medicine
  • Cancer
  • Administration of gallium nitrate to rats resulted in the formation of renal precipitates which occluded tubular lumina. When analyzed with a combination of scanning electron microscopy and x‐ray energy spectrometry, these precipitates were found to contain gallium complexed with calcium and phosphate. Injection of gallium nitrate also resulted in hypercalciuria, although serum calcium levels remained unaltered. Administration of an osmotic diuretic, isosorbide, prior to gallium treatment… CONTINUE READING
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