Gallium arsenide selectively suppresses antigen processing by splenic macrophages for CD4+ T cell activation.

@article{Lewis1996GalliumAS,
  title={Gallium arsenide selectively suppresses antigen processing by splenic macrophages for CD4+ T cell activation.},
  author={Timothy A. Lewis and Albert E. Munson and Kathleen L McCoy},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1996},
  volume={278 3},
  pages={1244-51}
}
Gallium arsenide (GaAs) is an intermetallic compound used in the electronics industry as a semiconductor. Acute exposure of animals to GaAs suppresses various immune functions. We investigated the effects of GaAs on immunocompetency with emphasis on macrophages. Mice were given 12.5 to 200 mg/kg GaAs i.p., and immune parameters were examined 1 or 5 days later. Chemically exposed mice did not display alteration in spienic cellular composition. Despite this, primary in vitro humoral response to… CONTINUE READING