Gallium(III) complexes of NOTA-bis (phosphonate) conjugates as PET radiotracers for bone imaging.

@article{Holub2015GalliumIIICO,
  title={Gallium(III) complexes of NOTA-bis (phosphonate) conjugates as PET radiotracers for bone imaging.},
  author={Jan Holub and Marian Meckel and Vojtěch Kub{\'i}{\vc}ek and Frank Roesch and Petr Hermann},
  journal={Contrast media & molecular imaging},
  year={2015},
  volume={10 2},
  pages={122-34}
}
Ligands with geminal bis(phosphonic acid) appended to 1,4,7-triazacyclonone-1,4-diacetic acid fragment through acetamide (NOTAM(BP) ) or methylenephosphinate (NO2AP(BP) ) spacers designed for (68) Ga were prepared. Ga(III) complexation is much faster for ligand with methylenephosphinate spacer than that with acetamide one, in both chemical (high reactant concentrations) and radiolabeling studies with no-carrier-added (68) Ga. For both ligands, formation of Ga(III) complex was slower than that… CONTINUE READING
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