Corpus ID: 201104255

Gallic acid inhibits LPS induced hypertrophic scar inflammation via toll-like receptor 4 / nuclear factor-κB / peroxisome proliferator-activated receptor γ signaling

@inproceedings{Fan2018GallicAI,
  title={Gallic acid inhibits LPS induced hypertrophic scar inflammation via toll-like receptor 4 / nuclear factor-κB / peroxisome proliferator-activated receptor γ signaling},
  author={Pengju Fan and Shu-yue Chen and Z. Li and Xinghua Yang and Shaorong Lei and Wuyuan Tan},
  year={2018}
}
Prolonged and enhanced inflammation is a common pathogenic feature of hypertrophic scars (HTS). Gallic acid (GA) is a naturally occurring plant phenol with lots of pharmacological activities, including antimicrobial, anti-inflammatory, anticancer, antioxidant, and anti-fibrosis effects. The objective of this study was to evaluate the effects of GA in LPS induced inflammatory response. Results suggest that there is significant production of TNF-α, IL6, IL-1β, and IL-8 in HSFs treated with LPS… Expand

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