Gallic acid induces apoptosis via caspase-3 and mitochondrion-dependent pathways in vitro and suppresses lung xenograft tumor growth in vivo.

@article{Ji2009GallicAI,
  title={Gallic acid induces apoptosis via caspase-3 and mitochondrion-dependent pathways in vitro and suppresses lung xenograft tumor growth in vivo.},
  author={Bin-Chuan Ji and Wu-Huei Hsu and J. Yang and T. Hsia and Chi-Cheng Lu and Jo-Hua Chiang and Jiun-Long Yang and Ching-Hsiung Lin and Jen-Jyh Lin and Lee-Jen Wu Suen and W. Gibson Wood and J. Chung},
  journal={Journal of agricultural and food chemistry},
  year={2009},
  volume={57 16},
  pages={
          7596-604
        }
}
Several studies have shown that gallic acid (GA) induces apoptosis in different cancer cell lines, whereas the mechanism of action of GA-induced apoptosis at the molecular level in human non-small-cell lung cancer NCI-H460 cells is not well-known. Here, GA decreasing the percentage of viable NCI-H460 cells was investigated; GA-induced apoptosis involved G2/M phase arrest and intracellular Ca(2+) production, the loss of mitochondrial membrane potential (DeltaPsi(m)), and caspase-3 activation… Expand
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