Gallbladder disease in patients with primary sclerosing cholangitis.

@article{Brandt1988GallbladderDI,
  title={Gallbladder disease in patients with primary sclerosing cholangitis.},
  author={D. J. Brandt and R. Maccarty and J. Charboneau and N. LaRusso and R. Wiesner and J. Ludwig},
  journal={AJR. American journal of roentgenology},
  year={1988},
  volume={150 3},
  pages={
          571-4
        }
}
We evaluated the gallbladders of 121 patients who had well-documented primary sclerosing cholangitis. Sonograms, cholangiograms, and CT scans were reviewed, and the findings were correlated with surgical or autopsy findings, when available. Pathologic examination of the gallbladder was available in 55 (45%) of the 121 patients; of these, 49 (89%) had abnormal gallbladders. Ninety-three of the 121 patients had one or more radiologic examinations of the gallbladder: 77 had sonograms, 80 had… Expand
Gallbladder disease in patients with primary sclerosing cholangitis.
TLDR
Gallbladder disease is common in patients with PSC, and Dysplasia and carcinoma are commonly found in gallbladder epithelium, suggesting that regular examination of thegallbladder in PSC patients could be of value for early detection of a gallbladders mass lesion. Expand
Gallbladder and pancreatic disease in patients with primary sclerosing cholangitis
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Gallbladder and pancreatic abnormalities are common in PSC and gallbladder mass lesions regardless of their size are frequently malignant in P SC, and data support an inflammation-fibrosis-dysplasia-carcinoma sequence of the gallbladders epithelium. Expand
Gallbladder disease in patients with primary sclerosing cholangitis.
TLDR
Gallbladder disease is common in patients with PSC, and Dysplasia and carcinoma are commonly found in gallbladder epithelium, suggesting that regular examination of thegallbladder in PSC patients could be of value for early detection of a gallbladders mass lesion. Expand
Likelihood of Malignancy in Gallbladder Polyps and Outcomes Following Cholecystectomy in Primary Sclerosing Cholangitis
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Cholecystectomy in patients with PSC is associated with a high morbidity and the Child-Pugh score was the only predictor of postoperative outcomes in the multivariate model. Expand
In primary sclerosing cholangitis, gallbladder polyps are frequently malignant
TLDR
Gallbladder neoplasms in PSC patients are malignant in approximately 40–60% of the cases, and the presence of gallbladder epithelial cell dysplasia suggests a Dysplasia-carcinoma sequence in P SC similar to that observed in ulcerative colitis. Expand
In primary sclerosing cholangitis, gallbladder polyps are frequently malignant.
TLDR
Gallbladder neoplasms in PSC patients are malignant in approximately 40–60% of the cases, and the presence of gallbladder epithelial cell dysplasia suggests a Dysplasia-carcinoma sequence in P SC similar to that observed in ulcerative colitis. Expand
Outcome of gallbladder polyps in patients with primary sclerosing cholangitis
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One third of GB polyps in patients with PSC who underwent cholecystectomy become malignant or developed dysplasia, and a GB polyp at first diagnosis of at least 1 cm in size was a good predictor for malignant lesions of GB or GB Dysplasia. Expand
Primary sclerosing cholangitis: sonographic findings
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Despite its inability to exclude intrahepatic duct disease, sonography is useful in diagnosing and following PSC. Expand
Original article Outcome of gallbladder polyps in patients with primary sclerosing cholangitis
TLDR
A GB polyp at first diagnosis of at least 1 cm in size was a good predictor for malignant lesions of GB or GB dysplasia in patients with PSC who underwent cholecystectomy, and careful monitoring of the progression ofGB polyp size over time with periodical assessment by ultrasound may be an option. Expand
Frequency, Risk Factors, and Outcome of Gallbladder Polyps in Patients With Primary Sclerosing Cholangitis: A Case‐Control Study
TLDR
GBPs may be frequently seen in patients with primary sclerosing cholangitis and patients with PSC may benefit from cholecystectomy, regardless of the size of the polyp. Expand
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References

Radiological features of sclerosing cholangitis.
TLDR
Retrograde, operative or percutaneous transhepatic cholangiograms were analysed in 14 patients with primary sclerosing cholangsitis, finding widespread and characteristic abnormalities including multiple strictures, areas of dilatation, pseudo-diverticula and pruning of intrap hepatic radicles. Expand