Galiellalactone Inhibits Stem Cell-Like ALDH-Positive Prostate Cancer Cells

@inproceedings{Hellsten2011GaliellalactoneIS,
  title={Galiellalactone Inhibits Stem Cell-Like ALDH-Positive Prostate Cancer Cells},
  author={Rebecka Hellsten and Martin H Johansson and Anna Dahlman and O lov Sterner and Anders Bjartell},
  booktitle={PloS one},
  year={2011}
}
Galiellalactone is a potent and specific inhibitor of STAT3 signaling which has been shown to possess growth inhibitory effects on prostate cancer cells expressing active STAT3. In this study we aimed to investigate the effect of galiellalactone on prostate cancer stem cell-like cells. We explored the expression of aldehyde dehydrogenase (ALDH) as a marker for cancer stem cell-like cells in different human prostate cancer cell lines and the effects of galiellalactone on ALDH expressing (ALDH… CONTINUE READING