Galectin-9 in physiological and pathological conditions

@article{Hirashima2002Galectin9IP,
  title={Galectin-9 in physiological and pathological conditions},
  author={Mitsuomi Hirashima and Yumiko Kashio and Nozomu Nishi and Akira Yamauchi and Tada-Atsu Imaizumi and Toshiro Kageshita and Naoki Saita and Takanori Nakamura},
  journal={Glycoconjugate Journal},
  year={2002},
  volume={19},
  pages={593-600}
}
We first cloned galectin-9 (Gal-9)/ecalectin as a T cell-derived eosinophil chemoattractant. Gal-9 plays a role in not only accumulation but also activation of eosinophils in experimental allergic models and human allergic patients, because Gal-9 induces eosinophil chemoattraction in vitro and in vivo and activates eosinophils in many aspects. Gal-9 requires divalent galactoside-binding activity but not the linker peptide of Gal-9 to exhibit its biological functions, and an unidentified matrix… CONTINUE READING
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Possible involvement of interferongammma in eosinophil adhesion by upregulating Galectin9 expression on the fibroblastic cell surface

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