Galectin-8: a matricellular lectin with key roles in angiogenesis.

  title={Galectin-8: a matricellular lectin with key roles in angiogenesis.},
  author={M. Fernanda Troncoso and F{\'a}tima Ferragut and Mar{\'i}a L Bacigalupo and V{\'i}ctor M C{\'a}rdenas Delgado and Lorena G Nugnes and Lucas Daniel Gentilini and Diego Jose Laderach and Carlota Wolfenstein-Todel and Daniel Compagno and Gabriel A. Rabinovich and Mar{\'i}a Teresa Elola},
  volume={24 10},
Galectin-8 (gal-8) is a "tandem-repeat"-type galectin, containing two carbohydrate recognition domains connected by a linker peptide. gal-8 is expressed both in the cytoplasm and nucleus in vascular endothelial cells (ECs) from normal and tumor-associated blood vessels, and in lymphatic endothelial cells. Herein, we describe a novel role for gal-8 in the regulation of vascular and lymphatic angiogenesis and provide evidence of its critical implications in tumor biology. Functional assays… CONTINUE READING
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