Galectin-4 in normal tissues and cancer

  title={Galectin-4 in normal tissues and cancer},
  author={Margaret E. Huflejt and Hakon Leffler},
  journal={Glycoconjugate Journal},
Galectin-4 belongs to a subfamily of galectins composed of two carbohydrate recognition domains within the same peptide chain. The two domains have all the conserved galectin signature amino acids, but their overall sequences are only approximately 40% identical. Both domains bind lactose with a similar affinity as other galectins, but their respective preferences for other disaccharides, and larger saccharides, are distinctly different. Thus galectin-4 has a property of a natural cross-linker… CONTINUE READING