Galectin-3 type-C self-association on neutrophil surfaces; The carbohydrate recognition domain regulates cell function.

Abstract

Galectin-3 is an endogenous β-galactoside-binding lectin comprising a carbohydrate recognition domain (CRD) linked to a collagen-like N-domain. Both domains are required for galectin-3 to induce cellular effects; a C-terminal fragment of galectin-3, galectin-3C, containing the CRD but lacking the N-domain, binds cell surface glycoconjugates but does not… (More)
DOI: 10.1002/JLB.3A0317-110R

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