Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation.

@article{Saegusa2008Galectin3PK,
  title={Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation.},
  author={Jun Saegusa and Daniel K. Hsu and Wei Liu and Ichiro Kuwabara and Yasuko Kuwabara and Lan Yu and Fu-tong Liu},
  journal={The Journal of investigative dermatology},
  year={2008},
  volume={128 10},
  pages={
          2403-11
        }
}
Keratinocytes undergo apoptosis in a variety of physiological and pathological conditions. Galectin-3 is a member of a family of beta-galactoside-binding animal lectins expressed abundantly in keratinocytes and other epithelial cells. Here, we have studied the regulatory role of galectin-3 in keratinocyte apoptosis by using cells from gene-targeted galectin-3 null (gal3(-/-)) mice. We showed that galectin-3 mRNA was transiently upregulated in ultraviolet-B (UVB)-irradiated wild-type… CONTINUE READING

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Pattern of galectins expression in actinic cheilitis with different risks of malignant transformation.

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