Galectin-3 is induced in rheumatoid arthritis synovial fibroblasts after adhesion to cartilage oligomeric matrix protein.

@article{Neidhart2005Galectin3II,
  title={Galectin-3 is induced in rheumatoid arthritis synovial fibroblasts after adhesion to cartilage oligomeric matrix protein.},
  author={M Neidhart and Frank Zaucke and Rebecca S Von Knoch and Astrid Juengel and Beat Michel and Renate Erika Gay and Steffen Gay},
  journal={Annals of the rheumatic diseases},
  year={2005},
  volume={64 3},
  pages={419-24}
}
BACKGROUND Galectin-3 is expressed in the synovial tissue of patients with rheumatoid arthritis (RA), particularly at sites of joint destruction. OBJECTIVE To explore the possibilities that galectin-3 is induced either by proinflammatory cytokines or by adhesion to cartilage components. METHODS Cell culture plates were coated with fibronectin, collagens I-VI, or cartilage oligomeric matrix protein (COMP), and the suspended cells were then added. The medium was changed after 1 hour at 37… CONTINUE READING

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