Galectin-3 interacts with naive and primed neutrophils, inducing innate immune responses.

@article{Nieminen2005Galectin3IW,
  title={Galectin-3 interacts with naive and primed neutrophils, inducing innate immune responses.},
  author={Julie Nieminen and Christian St-Pierre and Sachiko Sato},
  journal={Journal of leukocyte biology},
  year={2005},
  volume={78 5},
  pages={1127-35}
}
The neutrophil is the first line of defense against infection. As a part of the innate immune response, neutrophils start to emigrate from blood to an affected site and their state is altered from passively circulating naïve to primed, and then to fully activated. The extent of neutrophil activation and their subsequent response varies depending on the stimuli and environment that neutrophils encounter. Because neutrophils can also induce deleterious effects on host tissues, tight regulation of… CONTINUE READING