Galectin-3 interacts with components of the nuclear ribonucleoprotein complex

  title={Galectin-3 interacts with components of the nuclear ribonucleoprotein complex},
  author={Katharina Fritsch and Marco Mernberger and Andrea Nist and Thorsten Stiewe and Alexander Brehm and Ralf Jacob},
  booktitle={BMC Cancer},
The multifunctional β-galactoside-binding protein galectin-3 is found in many distinct subcellular compartments including the cell nucleus. Expression and distribution of galectin-3 between the cell nucleus and the cytosol changes during cell differentiation and cancer development. Nuclear functions of galectin-3 and how they contribute to tumorigenesis are not understood. In order to identify nuclear galectin-3 interaction partners, we used affinity chromatography and co-immunoprecipitation… CONTINUE READING


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