Galectin-3 interaction with Thomsen-Friedenreich disaccharide on cancer-associated MUC1 causes increased cancer cell endothelial adhesion.

@article{Yu2007Galectin3IW,
  title={Galectin-3 interaction with Thomsen-Friedenreich disaccharide on cancer-associated MUC1 causes increased cancer cell endothelial adhesion.},
  author={L G Yu and Nigel J Andrews and Qicheng Zhao and Daniel McKean and Jennifer F Williams and Lucy J Connor and Oleg V Gerasimenko and John Hilkens and Jun Hirabayashi and Kenichi Kasai and Jonathan Michael Rhodes},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 1},
  pages={773-81}
}
Patients with metastatic cancer commonly have increased serum galectin-3 concentrations, but it is not known whether this has any functional implications for cancer progression. We report that MUC1, a large transmembrane mucin protein that is overexpressed and aberrantly glycosylated in epithelial cancer, is a natural ligand for galectin-3. Recombinant galectin-3 at concentrations (0.2-1.0 microg/ml) similar to those found in the sera of patients with metastatic cancer increased adhesion of… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 116 extracted citations

Similar Papers

Loading similar papers…