Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems.

Abstract

Many invasive bacteria establish pathogen-containing vacuoles (PVs) as intracellular niches for microbial growth. Immunity to these infections is dependent on the ability of host cells to recognize PVs as targets for host defense. The delivery of several host defense proteins to PVs is controlled by IFN-inducible guanylate binding proteins (GBPs), which… (More)
DOI: 10.1073/pnas.1615771114

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Cite this paper

@article{Feeley2017Galectin3DA, title={Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems.}, author={Eric M. Feeley and Danielle M Pilla-Moffett and Erin E. Zwack and Anthony S. Piro and Ryan H. Finethy and Joseph P Kolb and Jennifer S. Martinez and Igor E Brodsky and J{\"{o}rn Coers}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2017}, volume={114 9}, pages={E1698-E1706} }