Galectin 3 Regulates HCC cell invasion by RhoA and MLCK activation

  title={Galectin 3 Regulates HCC cell invasion by RhoA and MLCK activation},
  author={Nobuko Serizawa and Jijiang Tian and Hiroo Fukada and Korn{\'e}lia Baghy and Fiona Scott and Xiangling Chen and Zsofia A. Kiss and Kristin A. Olson and Dan Hsu and Fu-tong Liu and Natalie J. T{\"o}r{\"o}k and Bin Zhao and Joy Xiaosong Jiang},
  booktitle={Laboratory Investigation},
Hepatocellular carcinoma (HCC) carries a poor prognosis with no effective treatment available other than liver transplantation for selected patients. Vascular invasion of HCC is one of the most important negative predictor of survival. As the regulation of invasion of HCC cells is not well understood, our aim was to study the mechanisms by which galectin 3, a β-galactosidase-binding lectin mediates HCC cell migration. HCC was induced by N-diethylnitrosamine in wild-type and galectin 3−/− mice… CONTINUE READING
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Epigenetic Regulation of Galectin-3 Expression by beta1 Integrins Promotes Cell Adhesion and Migration

  • C Margadant, I van den Bout, AL van Boxtel, VL Thijssen, A. Sonnenberg
  • The Journal of biological chemistry
  • 2012
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