Galectin-3 Regulates Atrial Fibrillation Remodeling and Predicts Catheter Ablation Outcomes

  title={Galectin-3 Regulates Atrial Fibrillation Remodeling and Predicts Catheter Ablation Outcomes},
  author={Yoshio Takemoto and Rafael J. Ramirez and Miki Yokokawa and Kuljeet Kaur and Daniela Ponce-Balbuena and Mohamad C. Sinno and B Cicero Willis and Hamid Ghanbari and Steven R. Ennis and Guadalupe Guerrero-Serna and Bettina C. Henzi and Rakesh Latchamsetty and Roberto Ramos-Mondrag{\'o}n and Hassan A-A Musa and Raphael P. Martins and Sandeep V. Pandit and Sami F. Noujaim and Thomas Christopher Crawford and Krit Jongnarangsin and Frank Pelosi and Frank M Bogun and Aman Chugh and Omer Berenfeld and Fred Morady And Frank Pelosid Morady and Hakan Oral and Jos{\'e} Jalife},
  booktitle={JACC. Basic to translational science},
OBJECTIVES To determine whether Gal-3 mediates sustained atrial fibrillation (AF)-induced atrial structural and electrical remodeling and contributes to AF perpetuation. BACKGROUND Galectin-3 (Gal-3) mediates extracellular matrix remodeling in heart failure, but its role in AF progression remains unexplored. METHODS We examined intracardiac blood samples from patients with AF (N=55) to identify potential biomarkers of AF recurrence. In a sheep model of tachypacing-induced AF (N=20), we… CONTINUE READING
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