Galectin-3, a marker for vacuole lysis by invasive pathogens.

@article{Paz2010Galectin3AM,
  title={Galectin-3, a marker for vacuole lysis by invasive pathogens.},
  author={Irit Paz and Martin Sachse and Nicolas Thomas Mathieu Dupont and Joelle Mounier and Cecilia Cederfur and Jost Enninga and Hakon Leffler and Françoise Poirier and Marie-Christine Prevost and Frank Lafont and Philippe J Sansonetti},
  journal={Cellular microbiology},
  year={2010},
  volume={12 4},
  pages={
          530-44
        }
}
Shigella bacteria invade macrophages and epithelial cells and following internalization lyse the phagosome and escape to the cytoplasm. Galectin-3, an abundant protein in macrophages and epithelial cells, belongs to a family of beta-galactoside-binding proteins, the galectins, with many proposed functions in immune response, development, differentiation, cancer and infection. Galectins are synthesized as cytosolic proteins and following non-classical secretion bind extracellular beta… CONTINUE READING
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