Corpus ID: 54873894

Galectin-12 colocalizes with splicing factor-rich speckles and shuttles between the nucleus and cytoplasm in colon cancer cells

@inproceedings{Katzenmaier2018Galectin12CW,
  title={Galectin-12 colocalizes with splicing factor-rich speckles and shuttles between the nucleus and cytoplasm in colon cancer cells},
  author={Eva Katzenmaier and Hans-Juergen Stark and J. Gebert and J. Kopitz},
  year={2018}
}
  • Eva Katzenmaier, Hans-Juergen Stark, +1 author J. Kopitz
  • Published 2018
  • Biology
  • Several members of the glycan-binding family of galectins have been linked to colon cancer initiation and progression while the role of galectin-12 in this malignancy is largely unexplored. In previous studies we observed expression of galectin-12 in normal colon epithelium in contrast to its lack of expression in colorectal cancer tissues. In order to gain insight into its molecular function we established a genetically engineered colon cancer model cell line, which facilitates inducible and… CONTINUE READING
    2 Citations

    Figures from this paper

    References

    SHOWING 1-10 OF 80 REFERENCES
    Characterization of the nuclear import pathways of galectin-3.
    • 48
    • PDF
    Nuclear transport of galectin-3 and its therapeutic implications.
    • 46
    Transport of galectin-3 between the nucleus and cytoplasm. I. Conditions and signals for nuclear import.
    • 49
    • Highly Influential
    • PDF
    Galectin-3 Translocates to the Perinuclear Membranes and Inhibits Cytochrome c Release from the Mitochondria
    • 280
    • PDF
    Changes in the expression and subcellular distribution of galectin-3 in clear cell renal cell carcinoma
    • 23
    Regulation of cancer-related gene expression by galectin-3 and the molecular mechanism of its nuclear import pathway
    • 63
    Identification of galectin-3 as a factor in pre-mRNA splicing.
    • 370
    • PDF