Galectin-1 triggers epithelial-mesenchymal transition in human hepatocellular carcinoma cells.

@article{Bacigalupo2015Galectin1TE,
  title={Galectin-1 triggers epithelial-mesenchymal transition in human hepatocellular carcinoma cells.},
  author={Mar{\'i}a L Bacigalupo and Malena Manzi and Mar{\'i}a Victoria Espelt and Lucas Daniel Gentilini and Daniel Compagno and Diego Jose Laderach and Carlota Wolfenstein-Todel and Gabriel A. Rabinovich and Maria Fernanda Troncoso},
  journal={Journal of cellular physiology},
  year={2015},
  volume={230 6},
  pages={
          1298-309
        }
}
Galectin-1 (Gal1), a β-galactoside-binding protein abundantly expressed in tumor microenvironments, is associated with the development of metastasis in hepatocellular carcinomas (HCC). However, the precise roles of Gal1 in HCC cell invasiveness and dissemination are uncertain. Here, we investigated whether Gal1 mediate epithelial-mesenchymal transition (EMT) in HCC cells, a key process during cancer progression. We used the well-differentiated and low invasive HepG2 cells and performed 'gain-of… CONTINUE READING
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