Galectin-1-specific inhibitors as a new class of compounds to treat HIV-1 infection.

Abstract

Despite significant improvements, antiretroviral therapies against HIV-1 are plagued by a high frequency of therapeutic failures that have been associated with acquisition of drug resistance. We recently reported that HIV-1 exploits a host glycan binding protein, galectin-1, to increase its attachment to host cells, thereby increasing its overall… (More)
DOI: 10.1128/AAC.05595-11

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