Galectin-1 is a major receptor for ganglioside GM1, a product of the growth-controlling activity of a cell surface ganglioside sialidase, on human neuroblastoma cells in culture.

Abstract

Cell density-dependent inhibition of growth and neural differentiation in the human neuroblastoma cell line SK-N-MC are associated with a ganglioside sialidase-mediated increase of GM1 and lactosylceramide at the cell surface. Because these glycolipids expose galactose residues, we have initiated the study of the potential role of galectins in such cellular… (More)

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@article{Kopitz1998Galectin1IA, title={Galectin-1 is a major receptor for ganglioside GM1, a product of the growth-controlling activity of a cell surface ganglioside sialidase, on human neuroblastoma cells in culture.}, author={J{\"u}rgen Kopitz and Constantin von Reitzenstein and Maria Burchert and Michael Cantz and Hans Joachim Gabius}, journal={The Journal of biological chemistry}, year={1998}, volume={273 18}, pages={11205-11} }