Galectin-1 deficiency improves axonal swelling of motor neurones in SOD1(G93A) transgenic mice.

@article{Kobayakawa2015Galectin1DI,
  title={Galectin-1 deficiency improves axonal swelling of motor neurones in SOD1(G93A) transgenic mice.},
  author={Yuko Kobayakawa and Kunihiko Sakumi and Kosuke Kajitani and Toshihiko Kadoya and Hidenori Horie and Jun-ichi Kira and Yusaku Nakabeppu},
  journal={Neuropathology and applied neurobiology},
  year={2015},
  volume={41 2},
  pages={227-44}
}
AIMS Galectin-1, a member of the β-galactoside-binding lectin family, accumulates in neurofilamentous lesions in the spinal cords of both sporadic and familial amyotrophic lateral sclerosis (ALS) patients with a superoxide dismutase 1 gene (SOD1) mutation (A4V). The aim of this study was to evaluate the roles of endogenous galectin-1 in the pathogenesis of ALS. METHODS Expression of galectin-1 in the spinal cord of mutant SOD1 transgenic (SOD1(G93A) ) mice was examined by pathological… CONTINUE READING
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