Galcanezumab: First Global Approval

  title={Galcanezumab: First Global Approval},
  author={Yvette N. Lamb},
  • Yvette N. Lamb
  • Published 2018
  • Medicine
  • Drugs
  • Galcanezumab-gnlm (Emgality™; Eli Lilly and Company), hereafter galcanezumab, is a humanized monoclonal antibody against the calcitonin gene-related peptide (CGRP) ligand. A potent vasodilator, CGRP is implicated in nociceptive transmission and migraine pathogenesis. In September 2018, the US FDA approved galcanezumab as a once-monthly subcutaneous injection for the preventive treatment of migraine in adults. In the same month, the EMA issued a positive opinion for galcanezumab for the… CONTINUE READING
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