Galatosylation and sialylation of mammalian glycoproteins produced by baculovirus-madiated gene expression in insect cells

@article{Yun2005GalatosylationAS,
  title={Galatosylation and sialylation of mammalian glycoproteins produced by baculovirus-madiated gene expression in insect cells},
  author={Eun-Young Yun and Tae-Won Goo and Sung-Wan Kim and Kwang-Ho Choi and J Hwang and Seok-Woo Kang and O. -Yu Kwon},
  journal={Biotechnology Letters},
  year={2005},
  volume={27},
  pages={1035-1039}
}
The baculovirus expression vector system (BEVS) is used extensively for the production of proteins from exogenous cDNAs. However, BEVS is not ideal for pharmaceutical production of glycoproteins owing to the properties of the N-glycans in the expressed products and that insect cells lack several of the enzymes required for mammalian-type N-glycan synthesis. This study describes the effective mammalian-like production of glycoproteins, such as β-1,4-galactosyltransferase and α-2,6… CONTINUE READING