Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice

@article{Kita2012GalantamineIH,
  title={Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice},
  author={Yuki Kita and Yukio Ago and Erika Takano and Asako Fukada and Kazuhiro Takuma and Toshio T. Matsuda},
  journal={Psychopharmacology},
  year={2012},
  volume={225},
  pages={543-551}
}
Galantamine, a drug for the treatment of Alzheimer’s disease, has neuroprotection in several experimental models and stimulates adult neurogenesis in the rodent brain, but the exact mechanism remains unclear. This study examined whether galantamine affects the expression of neurotrophic/growth factors in the mouse hippocampus and prefrontal cortex. Nine-week-old male ddY mice were used. The mRNA levels of neurotrophic/growth factors were analyzed by a real-time quantitative PCR. The protein… CONTINUE READING