Galantamine improves apomorphine-induced deficits in prepulse inhibition via muscarinic ACh receptors in mice.

@article{Yano2009GalantamineIA,
  title={Galantamine improves apomorphine-induced deficits in prepulse inhibition via muscarinic ACh receptors in mice.},
  author={Koji Yano and Ken Koda and Yukio Ago and Haruo Kobayashi and Tsutomu Kawasaki and Kazuhiro Takuma and Toshio T. Matsuda},
  journal={British journal of pharmacology},
  year={2009},
  volume={156 1},
  pages={173-80}
}
BACKGROUND AND PURPOSE Galantamine, a weak acetylcholine esterase (AChE) inhibitor and allosteric potentiator of nicotinic ACh receptors (nAChRs), improves apomorphine-induced deficits in prepulse inhibition (PPI), sensory information-processing deficits, via a nAChR-independent mechanism. The present study examined the role of muscarinic ACh receptors (mAChRs) in the effect of galantamine, and studied the mechanism of galantamine-induced increases in prefrontal ACh levels in mice… CONTINUE READING