Galantamine blocks cloned Kv2.1, but not Kv1.5 potassium channels.

  title={Galantamine blocks cloned Kv2.1, but not Kv1.5 potassium channels.},
  author={Hai-xia Zhang and Wei Zhang and Hong-wei Jin and Xiao-Liang Wang},
  journal={Brain research. Molecular brain research},
  volume={131 1-2},
Galantamine is a cholinesterase inhibitor (AChEI) currently used in treatment of Alzheimer's disease (AD). In the present study, the effects of galantamine on currents of cloned Kv2.1 and Kv1.5 potassium channels were investigated by using patch-clamp whole cell recording techniques. Kv2.1 and Kv1.5 were stably expressed in HEK293 cells. Galantamine blocked Kv2.1 current in a concentration-dependent manner. When depolarizing from -50 to +40 mV, the IC50 of galantamine for inhibition of Kv2.1… CONTINUE READING