Galanin receptors in the rat gastrointestinal tract.

  title={Galanin receptors in the rat gastrointestinal tract.},
  author={Laura Anselmi and Salvatore L. Stella and Alexander J. Lakhter and Arlene A Hirano and Marcello Tonini and Catia Sternini},
  volume={39 3},
Galanin functions are mediated by three distinct G-protein-coupled receptors, galanin receptor 1 (GalR1), GalR2 and GalR3, which activate different intracellular signaling pathways. Here, we quantified mRNA levels of GalR1, GalR2 and GalR3 in the gastrointestinal tract using real time RT-PCR. GalR1 and GalR2 mRNAs were detected in all segments with the highest levels in the large intestine and stomach, respectively. GalR3 mRNA levels were quite low and mostly confined to the colon. We also… CONTINUE READING


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