Galanin receptor subtypes.

  title={Galanin receptor subtypes.},
  author={Theresa A. Branchek and Kelli E. Smith and Christophe Gerald and Mary W. Walker},
  journal={Trends in pharmacological sciences},
  volume={21 3},
The neuropeptide galanin, which is widely expressed in brain and peripheral tissues, exerts a broad range of physiological effects. Pharmacological studies using peptide analogues have led to speculation about multiple galanin receptor subtypes. Since 1994, a total of three G-protein-coupled receptor (GPCR) subtypes for galanin have been cloned (GAL1, gal2 and gal3). Potent, selective antagonists are yet to be found for any of the cloned receptors. Major challenges in this field include linking… CONTINUE READING
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