Galanin inhibits glucose-stimulated insulin release by a mechanism involving hyperpolarization and lowering of cytoplasmic free Ca2+ concentration.

@article{Ahrn1986GalaninIG,
  title={Galanin inhibits glucose-stimulated insulin release by a mechanism involving hyperpolarization and lowering of cytoplasmic free Ca2+ concentration.},
  author={Bo Ahr{\'e}n and P. O. G. Arkhammar and Per Olof Berggren and Tina Nilsson},
  journal={Biochemical and biophysical research communications},
  year={1986},
  volume={140 3},
  pages={1059-63}
}
The intrapancreatic neuropeptide galanin has been demonstrated to lower plasma insulin levels in vivo. The effects of this peptide on insulin secretion, cytoplasmic free Ca2+ concentration and membrane potential have now been studied in vitro. Glucose-stimulated insulin secretion was inhibited by galanin under these conditions, indicating a direct effect of the peptide on the beta-cells. The neuropeptide reversed both the increase in membrane potential and cytoplasmic free Ca2+ in response to… CONTINUE READING