Galanin Receptor 1 Deletion Exacerbates Hippocampal Neuronal Loss after Systemic Kainate Administration in Mice

@inproceedings{Schauwecker2010GalaninR1,
  title={Galanin Receptor 1 Deletion Exacerbates Hippocampal Neuronal Loss after Systemic Kainate Administration in Mice},
  author={Paula Elyse Schauwecker},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Galanin is a neuropeptide with a wide distribution in the central and peripheral nervous systems and whose physiological effects are mediated through three G protein-coupled receptor subtypes, GalR1, GalR2, and GalR3. Several lines of evidence indicate that galanin, as well as activation of the GalR1 receptor, is a potent and effective modulator of neuronal excitability in the hippocampus. METHODOLOGY/PRINCIPAL FINDINGS In order to test more formally the potential influence of… CONTINUE READING