Galanin (1–15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT: involvement of the raphe-hippocampal 5-HT neuron system

@article{Milln2015GalaninE,
  title={Galanin (1–15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT: involvement of the raphe-hippocampal 5-HT neuron system},
  author={Carmelo Mill{\'o}n and Antonio Flores-Burgess and Manuel Narv{\'a}ez and Dasiel O Borroto-Escuela and Luis J Sant{\'i}n and Belen Gago and Jos{\'e} {\'A}ngel Narv{\'a}ez and Kjell Fuxe and Zaida Diaz-Cabiale},
  journal={Brain Structure and Function},
  year={2015},
  volume={221},
  pages={4491-4504}
}
Galanin N-terminal fragment (1–15) [GAL(1–15)] is associated with depression-related and anxiogenic-like effects in rats. In this study, we analyzed the ability of GAL(1–15) to modulate 5-HT1A receptors (5-HT1AR), a key receptor in depression. GAL(1–15) enhanced the antidepressant effects induced by the 5-HT1AR agonist 8-OH-DPAT in the forced swimming test. These effects were stronger than the ones induced by Galanin (GAL). This action involved interactions at receptor level since GAL(1–15… CONTINUE READING

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