Galactosylation and Sialylation Levels of IgG Predict Relapse in Patients With PR3-ANCA Associated Vasculitis

@inproceedings{Kemna2017GalactosylationAS,
  title={Galactosylation and Sialylation Levels of IgG Predict Relapse in Patients With PR3-ANCA Associated Vasculitis},
  author={Michael Joseph Kemna and Rosina Plomp and Pieter van Paassen and Carolien A.M. Koeleman and Bas Cornelis Jansen and Jan Damoiseaux and Jan Willem Cohen Tervaert and Manfred Wuhrer},
  booktitle={EBioMedicine},
  year={2017}
}
OBJECTIVE The objective of our study is to investigate the Fc glycosylation profiles of both antigen-specific IgG targeted against proteinase 3 (PR3-ANCA) and total IgG as prognostic markers of relapse in patients with Granulomatosis with Polyangiitis (GPA). METHODS Seventy-five patients with GPA and a PR3-ANCA rise during follow-up were included, of whom 43 patients relapsed within a median period of 8 (2-16) months. The N-glycan at Asn297 of affinity-purified and denatured total IgG and PR3… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 77 REFERENCES

A Cross-platform Toolkit for Mass Spectrometry and Proteomics

  • Nature Biotechnology
  • 2012
VIEW 1 EXCERPT
HIGHLY INFLUENTIAL

Complement in ANCA-associated glomerulonephritis.

  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2017
VIEW 2 EXCERPTS