Galactosylated nanocrystallites of insoluble anticancer drug for liver-targeting therapy: an in vitro evaluation.

@article{Wei2010GalactosylatedNO,
  title={Galactosylated nanocrystallites of insoluble anticancer drug for liver-targeting therapy: an in vitro evaluation.},
  author={Wei Wei and Zhan-Guo Yue and Jian-Bo Qu and Hua Yue and Zhi-guo Su and Guanghui Ma},
  journal={Nanomedicine},
  year={2010},
  volume={5 4},
  pages={
          589-96
        }
}
AIM Low solubility in water has become an intrinsic property of many anticancer drugs, which poses a hurdle in the translation from the bench to the clinic. In this study, we developed a facile method to prepare 10-hydroxycamptothecin (HCPT) nanocrystallites and testified their feasibility for liver-targeting therapy. MATERIALS & METHODS HCPT nanocrystallites were prepared under the soft template effect of galactosylated chitosan. The internalization profile, intracellular trafficking, drug… CONTINUE READING

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