Galactosylated chitosan-polycaprolactone nanoparticles for hepatocyte-targeted delivery of curcumin.

  title={Galactosylated chitosan-polycaprolactone nanoparticles for hepatocyte-targeted delivery of curcumin.},
  author={Nuo Zhou and Xiaoli Zan and Zheng Shu Wang and Hua Y. Wu and Dengke Yin and Chunyan Liao and Ying Wan},
  journal={Carbohydrate polymers},
  volume={94 1},
Galactosylated chitosan-polycaprolactone (Gal-CH-PCL) copolymers with a galactosylation degree of around 10% and varied PCL percentages less than 40 wt% were synthesized and used to produce nanoparticles for delivering curcumin. Some nanoparticles with encapsulation efficiency of 70% or higher and sizes changing from 100 to 250 nm were able to deliver curcumin in a controlled manner. PCL content in Gal-CH-PCLs was found to be a key factor for governing the release behavior of nanoparticles… CONTINUE READING


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