• Corpus ID: 35137502

Galactose Metabolism in Bacteroides vulgatus from the Human Gut Microbiota

  title={Galactose Metabolism in Bacteroides vulgatus from the Human Gut Microbiota},
  author={Merlin Eric Hobbs and Howard J. Williams and Brandan S. Hillerich and Steven C. Almo and Frank M. Raushel},
A previously unknown metabolic pathway for the utilization of L-galactose was discovered in a prevalent gut bacterium, Bacteroides vulgatus. The new pathway consists of three previously uncharacterized enzymes that were found to be responsible for the conversion of L-galactose to D-tagaturonate. Bvu0219 (L-galactose dehydrogenase) was determined to oxidize L-galactose to L-galactono-1,5-lactone with kcat and kcat/Km values of 21 s −1 and 2.0 × 10 M−1 s−1, respectively. The kinetic product of… 

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