Galactokinase: structure, function and role in type II galactosemia

@article{Holden2004GalactokinaseSF,
  title={Galactokinase: structure, function and role in type II galactosemia},
  author={H. Holden and J. Thoden and D. Timson and R. Reece},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2004},
  volume={61},
  pages={2471-2484}
}
Abstract.The conversion of beta-D-galactose to glucose 1-phosphate is accomplished by the action of four enzymes that constitute the Leloir pathway. Galactokinase catalyzes the second step in this pathway, namely the conversion of alpha-D-galactose to galactose 1-phosphate. The enzyme has attracted significant research attention because of its important metabolic role, the fact that defects in the human enzyme can result in the diseased state referred to as galactosemia, and most recently for… Expand
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