Galactogogues: Medications That Induce Lactation

@article{Gabay2002GalactogoguesMT,
  title={Galactogogues: Medications That Induce Lactation},
  author={Michael P. Gabay},
  journal={Journal of Human Lactation},
  year={2002},
  volume={18},
  pages={274 - 279}
}
  • M. Gabay
  • Published 1 August 2002
  • Medicine
  • Journal of Human Lactation
Galactogogues are medications that aid in initiating and maintaining adequate milk production. Most exert their pharmacologic effects through interactions with dopamine receptors, resulting in increased prolactin levels and thereby augmenting milk supply. Metoclopramide remains the galactogogue of choice due to its documented record of efficacy and safety in women and infants. Domperidone crosses the blood brain barrier and into the breast milk to a lesser extent than metoclopramide, decreasing… 
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TLDR
The tactile stimulus to maternal nipples by the suckling infant prompts afferent impulses to effect the release of prolactin from the pituitary, which stimulates milk flow and enhances milk product.
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The principles of breastfeeding management are illustrated in 3 cases in this chapter, and patient with breast milk insufficiency can be managed by ensuring that a sucking stimulus of 30 minutes (15 minutes bilaterally) be present and repeated every 2-3 hours to provide adequate stimulation for prolactin release.
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TLDR
The principles of breastfeeding management are illustrated in 3 cases in this chapter and it is suggested that the mother should be directed to focus on pleasant associations while nursing to keep her from worrying about whether she will have enough milk.
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TLDR
Repeated nasal TRH administration between suckling episodes may improve defective lactation in puerperal women with inadequate lactation and no signs of hyperthyroidism.
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TLDR
The effect of metoclopramide therapy in 23 women who were delivered of premature infants and who were having difficulty maintaining milk production with milk expression was evaluated, finding milk expression did not produce any additional prolactin response in the treated women.
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TLDR
Growth hormone treatment increased milk volume in normal lactating women during early lactation, and all women treated with hGH showed a small increase in milk IGF-1 concentrations but the values remained within the range of values observed in women receiving the placebo treatment.
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TLDR
In the short term domperidone increases milk production in women with low milk supply and is detected at low levels in breast milk.
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