Galactogogues: Medications That Induce Lactation

  title={Galactogogues: Medications That Induce Lactation},
  author={Michael P. Gabay},
  journal={Journal of Human Lactation},
  pages={274 - 279}
  • M. Gabay
  • Published 1 August 2002
  • Medicine
  • Journal of Human Lactation
Galactogogues are medications that aid in initiating and maintaining adequate milk production. Most exert their pharmacologic effects through interactions with dopamine receptors, resulting in increased prolactin levels and thereby augmenting milk supply. Metoclopramide remains the galactogogue of choice due to its documented record of efficacy and safety in women and infants. Domperidone crosses the blood brain barrier and into the breast milk to a lesser extent than metoclopramide, decreasing… 
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A review of the evidence for the efficacy of popular pharmaceutical and herbal galactagogues revealed a dearth of high-quality clinical trials and mixed results, and controlled trials and analyses investigating these medicines are urgently warranted.
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Improved Lactation with Metoclopramide
The tactile stimulus to maternal nipples by the suckling infant prompts afferent impulses to effect the release of prolactin from the pituitary, which stimulates milk flow and enhances milk product.
Metoclopramide and breast feeding: efficacy and anterior pituitary responses of the mother and the child.
Prolactin cycling and the management of breast-feeding failure.
The principles of breastfeeding management are illustrated in 3 cases in this chapter, and patient with breast milk insufficiency can be managed by ensuring that a sucking stimulus of 30 minutes (15 minutes bilaterally) be present and repeated every 2-3 hours to provide adequate stimulation for prolactin release.
Prolactin cycling and the management of breast-feeding failure.
The principles of breastfeeding management are illustrated in 3 cases in this chapter and it is suggested that the mother should be directed to focus on pleasant associations while nursing to keep her from worrying about whether she will have enough milk.
Thyrotrophin-releasing hormone--a lactation-promoting agent?
Repeated nasal TRH administration between suckling episodes may improve defective lactation in puerperal women with inadequate lactation and no signs of hyperthyroidism.
Metoclopramide effect on faltering milk production by mothers of premature infants.
The effect of metoclopramide therapy in 23 women who were delivered of premature infants and who were having difficulty maintaining milk production with milk expression was evaluated, finding milk expression did not produce any additional prolactin response in the treated women.
Growth hormone stimulates galactopoiesis in healthy lactating women.
Growth hormone treatment increased milk volume in normal lactating women during early lactation, and all women treated with hGH showed a small increase in milk IGF-1 concentrations but the values remained within the range of values observed in women receiving the placebo treatment.
Effect of domperidone on milk production in mothers of premature newborns: a randomized, double-blind, placebo-controlled trial.
In the short term domperidone increases milk production in women with low milk supply and is detected at low levels in breast milk.