Galactocerebroside-phospholipid interactions in bilayer membranes.

@article{Ruocco1983GalactocerebrosidephospholipidII,
  title={Galactocerebroside-phospholipid interactions in bilayer membranes.},
  author={Martin J. Ruocco and G. Graham Shipley and Eric Oldfield},
  journal={Biophysical journal},
  year={1983},
  volume={43 1},
  pages={
          91-101
        }
}
Differential scanning calorimetry (DSC) and x-ray diffraction have been used to study the interaction of hydrated N-palmitoylgalactosylsphingosine (NPGS) and dipalmitoylphosphatidylcholine (DPPC). For mixtures containing less than 23 mol% NPGS, complete miscibility of NPGS into hydrated DPPC bilayers is observed in both the bilayer gel and liquid-crystal phases. X-ray diffraction data demonstrate insignificant differences in the DPPC-bilayer gel-phase parameters on incorporation of up to 23 mol… Expand
Interaction of cholesterol with galactocerebroside and galactocerebroside-phosphatidylcholine bilayer membranes.
TLDR
The interaction of the galactocerebroside, N-palmitoylgalactosylsphingosine, with cholesterol has been studied by differential scanning calorimetry (DSC) and x-ray diffraction and the unique thermal and structural behavior of NPGS-cholesterol dispersions is contrasted with the behavior of cholesterol-phosphatidycholine and cholesterol-sphingomyelin bilayers. Expand
Comparative study of the gel phases of ether- and ester-linked phosphatidylcholines.
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X-ray diffraction studies indicate that DHPC dispersions form a lamellar gel phase with dav congruent to 46 A both above and below the "subtransition", and it is suggested that the reduced dav observed for DHPC is due to an interdigitated lamellary gel phase which exists at all temperatures below the pretransition at 35 degrees C. Expand
Thermal and structural behavior of natural cerebroside 3-sulfate in bilayer membranes.
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2H-NMR was employed to consider the arrangement of a glycosphingolipid, N-(lignoceroyl-d47)galactosylceramide, in bilayers of the mono-unsaturated phospholipids host matrix, and spectra of the deuterated glycolipid 24-carbon fatty acid suggest that orientational order is low for a number of methylene groups near the methyl end of the chain. Expand
Long N-acyl fatty acids on sphingolipids are responsible for miscibility with phospholipids to form liquid-ordered phase.
  • P. Quinn
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • 2009
TLDR
The structure and thermotropic phase behaviour of aqueous dispersions of dipalmitoylphosphatidylcholine and glucosylceramide rich in C-24 fatty acyl residues was investigated by synchrotron X-ray diffraction methods and the role of the length of the N-acyl substituent of the sphingolipids in formation of complexes with phospholipid was discussed. Expand
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The continuous swelling behavior exhibited by the L(alpha) bilayer phase of C16:0-GalSulf is typical of lipids bearing a net negative charge and confirms that the presence of 100 mM Na(+) is insufficient to shield the charge contributed by the sulfate group. Expand
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Morphological characterization of N-24:1 delta 15(cis) sphingosylphosphorylcholine revealed no evidence of bilayer cylinder or tubule formation and suggested that changes to the polar interface/headgroup region imparted by the 2-hydroxy acyl species strongly influenced bilayer tubule and cylinder formation in GalCer. Expand
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A Characterization of the Phase Transitions in Saturated Monogalactosyldiacylglycerol-Water Systems Using Real-Time X-Ray Diffraction Methods
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Characterization of a quasicrystalline phase in codispersions of phosphatidylethanolamine and glucocerebroside.
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The results are interpreted as an arrangement of polar groups of the complex in a crystalline array and a quasicrystalline packing of the hydrocarbon chains predicated by packing problems in the bilayer core requiring disordering of the highly asymmetric chains. Expand
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