GalNAc-α-O-benzyl Inhibits NeuAcα2-3 Glycosylation and Blocks the Intracellular Transport of Apical Glycoproteins and Mucus in Differentiated HT-29 Cells

@article{Huet1998GalNAcObenzylIN,
  title={GalNAc-α-O-benzyl Inhibits NeuAcα2-3 Glycosylation and Blocks the Intracellular Transport of Apical Glycoproteins and Mucus in Differentiated HT-29 Cells },
  author={G. Huet and Sylviane Hennebicq-Reig and Carmen de Bolos and Fausto Ulloa and Th{\'e}cla Lesuffleur and Alain Barbat and V{\'e}ronique Carri{\`e}re and Isabelle Kim and Francisco X Real and Philippe Delannoy and Alain Zweibaum},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={141},
  pages={1311 - 1322}
}
Exposure for 24 h of mucus-secreting HT-29 cells to the sugar analogue GalNAc-alpha-O-benzyl results in inhibition of Galbeta1-3GalNAc:alpha2,3-sialyltransferase, reduced mucin sialylation, and inhibition of their secretion (Huet, G., I. Kim, C. de Bolos, J.M. Loguidice, O. Moreau, B. Hémon, C. Richet, P. Delannoy, F.X. Real., and P. Degand. 1995. J. Cell Sci. 108:1275-1285). To determine the effects of prolonged inhibition of sialylation, differentiated HT-29 populations were grown under… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 41 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 69 REFERENCES

Expression and function of a-2,3-sialyl- and a-1,3/1,4-fucosyltransferases

M. L. Majuri, R. Niemela, S. Tiisala, O. Renkonen, R. Renkonen
  • 1995
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Effect of benzyl-a-GalNac, an inhibitor of mucin glycosylation, on cancer-associated antigens, in human colon cancer cells

J. Huang, J. C. Byrd, W. H. Yoor, Y. S. Kim.
  • Oncol. Res. 4:507–515.
  • 1992
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Monoclonal antibodies reactive with mucin expressed in breast cancer.

  • Immunology and cell biology
  • 1989
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL