Gait impairments in Parkinson's disease

  title={Gait impairments in Parkinson's disease},
  author={Anat Mirelman and Paolo Bonato and Richard Camicioli and Terry D. Ellis and Nir Giladi and Jamie L. Hamilton and Chris J. Hass and Jeffrey M. Hausdorff and Elisa Pelosin and Quincy J. Almeida},
  journal={The Lancet Neurology},

Treatment options for postural instability and gait difficulties in Parkinson’s disease

A review that encompasses pathophysiological changes involved in axial motor impairments in Parkinson’s disease, pharmacological approaches, exercise, and physical therapy, improving physical activity levels, invasive and non-invasive neurostimulation, cueing interventions and wearable technology, and cognitive interventions is provided.

Gait alterations in Parkinson’s disease at the stage of hemiparkinsonism—A longitudinal study

Alterations of the swing time and double support time are already present even at the asymptomatic body side, and progress similarly, or even at faster pace, at this side, despite dopaminergic treatment, and deserve further investigation in larger, prospective studies.

Perception and Use of Compensation Strategies for Gait Impairment by Persons With Parkinson Disease

Compensation strategies are useful for all types of patients with PD, but the efficacy of the different strategies varies per person, and the patient-rated efficacy of compensation strategies is high but varies depending on the context in which they are applied.

A pathophysiological model of gait captures the details of the impairment of pace/rhythm, variability and asymmetry in Parkinsonian patients at distinct stages of the disease

The findings support the use of factor scores and of the model with respect to the single variables in gait staging in PD and help to evaluate if factors highlight gait differences between pwPD and healthy subjects (HS) and do it at earlier stages of disease compared to single variables.

Atypical Gait Cycles in Parkinson’s Disease

Atypical cycles have proved to be a valid biomarker to quantify subtle gait dysfunctions in PD patients and a strong correlation between the atypical cycles and the motor clinical score UPDRS-III was found.

Gait Abnormalities in Parkinson's Disease Are Associated with Extracellular Free-Water in the Substantia Nigra.

Gait rhythmic alterations associated positively with the free-water content in the right substantia nigra in PD, indicating that patients with more severe neurodegeneration extend the duration of stance phase, load response, and pre- Swing, as well as reduced duration of single support and swing time.

Detection and assessment of Parkinson's disease based on gait analysis: A survey

Neurological disorders represent one of the leading causes of disability and mortality in the world. Parkinson's Disease (PD), for example, affecting millions of people worldwide is often manifested

Fear of Falling Does Not Influence Dual-Task Gait Costs in People with Parkinson’s Disease: A Cross-Sectional Study

F does not appear to have a relevant effect on dual-task costs of gait when cognitive tasks are added during walking, and associations between FOF, cognition, and gait parameters under single-task and DT are described.



Progression of gait dysfunction in incident Parkinson's disease: Impact of medication and phenotype

Some features of gait are refractory to dopaminergic therapy, implicating a non‐dopaminergic contribution, and may explain more temporal gait disturbance in the postural instability and gait difficulty phenotype.

Gait and balance in Parkinson’s disease subtypes: objective measures and classification considerations

Clinical assessments of the disturbances seen in patients with the PIGD subtype are not consistent with objective measures; overlapping between the groups is seen in many objective features of gait and balance.

Postural instability and gait are associated with severity and prognosis of Parkinson disease

The results showed that severity of PIGD is a useful indicator of severity and prognosis in PD by itself, and the use of the TD subtype as a prognostic trait in PD is not supported.

SPARC: a new approach to quantifying gait smoothness in patients with Parkinson’s disease

The recently proposed spectral arc length measure (SPARC) is sensitive to Parkinson’s disease and PD medications and can be used of as another, complementary measure of the motor control of walking in PD.

Step length predicts executive dysfunction in Parkinson’s disease: a 3-year prospective study

The present study indicates that step length during a cognitive task when on medication is an independent predictor of future executive/attention decline, as well as regression models to determine whether gait predicts subsequent cognitive dysfunction.

Gait Rather Than Cognition Predicts Decline in Specific Cognitive Domains in Early Parkinson’s Disease

Novel evidence is provided for gait as a clinical biomarker for PD cognitive decline in early disease by predicting decline in fluctuating attention and visual memory, whereas baseline neuropsychological assessment performance did not predict decline.

New evidence for gait abnormalities among Parkinson’s disease patients who suffer from freezing of gait: insights using a body-fixed sensor worn for 3 days

It is demonstrated that freezers have altered gait variability and consistency during spontaneous community ambulation, even during optimal performance, and that these measures are associated with the impact of FOG on daily function.