Corpus ID: 67836861

Gait analysis in the pig ischemic stroke model to determine efficacy of iNSC therapy on motor function recovery

  title={Gait analysis in the pig ischemic stroke model to determine efficacy of iNSC therapy on motor function recovery},
  author={Trinh Nguyen},
OF INSC THERAPY ON MOTOR FUNCTION RECOVERY by TRINH UYEN NGUYEN (Under the Direction of Franklin D. West) ABSTRACT Most stroke survivors suffer from severe motor disabilities, including impaired manual dexterity and gait in the paretic limb. A novel stem cell therapy, induced pluripotent stem cellderived neural stem cells (iNSCs), has been shown to differentiate into neural cells and integrate into the stroked brain to reduce infarct size and improve motor recovery in rodents. However, there is… Expand


Gait analysis in a pre- and post-ischemic stroke biomedical pig model
Gait analysis of stroke injury is a highly sensitive detection method for changes in gait parameters in pig and supports that the pig may make a more clinically relevant animal model to facilitate treatment development for neurological conditions. Expand
Gait analysis as a method for assessing neurological outcome in a mouse model of stroke
Ameliorating stroke induced neurological deficits is one of the most important goals of stroke therapy. In order to improve stroke outcome, novel treatment approaches as well as animal stroke modelsExpand
A Comprehensive Analysis of Gait Impairment after Experimental Stroke and the Therapeutic Effect of Environmental Enrichment in Rats
  • Yonggang Wang, B. Bontempi, +4 authors Jialing Liu
  • Medicine
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2008
The results indicate that gait analysis provides great insight into various aspects of motor function changes in ischemic quadrupeds, and that environmental enrichment is beneficial in reducing a variety of poststroke gait impairments possibly through enhanced structural plasticity mechanisms within injured cortical neuronal networks underlying locomotor function. Expand
Gait Impairment in a Rat Model of Focal Cerebral Ischemia
The translational applicability of CatWalk XT in evaluating motor impairment and treatment efficacy remains to be limited at least in rats with severe corticostriatal infarct and loss of body weight. Expand
Automated quantitative gait analysis in animal models of movement disorders
The automated quantitative gait analysis test may be a useful tool to study both motor impairment and recovery associated with various neurological motor disorders. Expand
The CatWalk gait analysis in assessment of both dynamic and static gait changes after adult rat sciatic nerve resection
It is concluded that the CatWalk objectively detects dynamic and static gait impairments after sciatic nerve resection and future experiments are now required to prove which of these parameters are of particular interest to detect functional repair. Expand
Recovery of gait and other motor functions after stroke: novel physical and pharmacological treatment strategies.
  • S. Hesse
  • Psychology, Medicine
  • Restorative neurology and neuroscience
  • 2004
The gait-lab at Klinik Berlin developed and evaluated novel physical and pharmacological strategies promoting the repetitive practise of hemiparetic gait in line with the slogan: who wants to relearnExpand
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The data suggest intravenously transplanted human NSCs can migrate and differentiate in the rat brain with focal ischemia and improve functional recovery. Expand
Brain Activity Changes Associated With Treadmill Training After Stroke
Although the dorsal premotor cortex appears to play an important role in recovery of hand movements, evidence for the involvement of this region in lower extremity recovery was not found and rehabilitation-associated walking improvements are associated with cortical activation changes. Expand
Motor Recovery and Cortical Reorganization after Constraint-Induced Movement Therapy in Stroke Patients: A Preliminary Study
FMRI data provide preliminary evidence that gains in motor function produced by CIMT in chronic stroke patients may be associated with a shift in laterality of motor cortical activation toward the undamaged hemisphere. Expand