Gains in Statistical Power From Using a Dietary Biomarker in Combination With Self-reported Intake to Strengthen the Analysis of a Diet-Disease Association: An Example From CAREDS

@inproceedings{Freedman2010GainsIS,
  title={Gains in Statistical Power From Using a Dietary Biomarker in Combination With Self-reported Intake to Strengthen the Analysis of a Diet-Disease Association: An Example From CAREDS},
  author={Laurence S Freedman and Nata{\vs}a Tasevska and Victor Kipnis and Arthur S Schatzkin and Julie A. Mares and Lesley T Tinker and Nancy Potischman},
  booktitle={American journal of epidemiology},
  year={2010}
}
A major problem in detecting diet-disease associations in nutritional cohort studies is measurement error in self-reported intakes, which causes loss of statistical power. The authors propose using biomarkers correlated with dietary intake to strengthen analyses of diet-disease hypotheses and to increase statistical power. They consider combining self-reported intakes and biomarker levels using principal components or a sum of ranks and relating the combined measure to disease in conventional… CONTINUE READING